Amyloid accumulation may play a role in the development of Alzheimer’s disease, but it may not be enough to diagnose the disease, according to a study published in JAMA Neurology. Small-vessel cerebrovascular disease, which manifests as white matter hyperintensities, may also play a role in the development of the disease, the study said, and the combined factors appear to be involved in manifestation of disease. The researchers used C-11-PIB-PET imaging to detect amyloid buildup and structural MRI to measure WMH. "The findings suggest a role of small-vessel cerebrovascular disease in the clinical presentation of AD and point to the importance of incorporating WMH into the formulation of pathogenic models of the disease," the researchers wrote.
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