Giving tranexamic acid with the anticoagulant clopidogrel before coronary artery bypass surgery was linked with lower odds of bleeding as well as improved platelet function, according to a study in the journal JAMA Surgery. Preoperative clopidogrel by itself was associated with increased bleeding risk and greater need for transfusions. "This extra protection [provided by tranexamic acid] against impaired platelet function improved the bleeding and transfusion outcomes in patients with clopidogrel persistence to a comparable level as that in patients with clopidogrel cessation," according to the study.
Combination lowers bleeding risk for bypass patients
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