Method could prevent GVHD in bone marrow transplants

03/6/2013 | Genetic Engineering & Biotechnology News

Blocking the Notch signaling pathway in donor cells may reduce the risk of graft-versus-host disease after bone marrow transplants, a University of Michigan team reports in the Journal of Clinical Investigation. Targeting a ligand-receptor pair in the Notch signaling pathway prevented the disease in mice and did not cause adverse effects or affect the ability of the transplanted cells to fight cancer, according to the study. The findings open new routes for possible treatments of T cell-related conditions in transplants, an investigator said.

View Full Article in:

Genetic Engineering & Biotechnology News

Published in Briefs:

SmartBrief Job Listings for Health Care

Job Title Company Location
Director of Behavioral Health Operations
Meridian Health Plan
Detroit, MI
Medical Director
PacificSource
Bend, OR
Clinical Appeals RN
MJHS
Brooklyn, NY
Director of Clinical Operations
Meridian Health Plan
Detroit, MI
Sr. Director, Regulatory Compliance Intelligence and Outreach
Johnson & Johnson
New Brunswick, NJ