An analysis of gene expressions in peripheral blood monocytes of 22 children found those with type 1 diabetes who had severely deviated monocyte expression profiles showed higher blood glucose levels than patients whose deviations were mild. Multiple perturbations were also observed in genetic pathways associated with metabolism and survival of the cells, researchers noted in Diabetes. Monocyte phenotype could be used as a biomarker to indicate disease progression before and after onset in type 1 diabetes, researchers said.
Gene profile linked to glucose control in type 1 diabetes
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