Study: Biomarkers help predict MCI progression to Alzheimer's

03/21/2013 | MedPage Today (free registration)

Cerebrospinal fluid biomarkers, such as amyloid B-42, T-tau and P-tau, could help pinpoint patients with mild cognitive impairment who are likely to develop Alzheimer's disease, according to findings presented at a neurology meeting. Patients with MCI who progressed to Alzheimer's in three years had lower baseline levels of amyloid B-42 and higher baseline T-tau and P-tau compared with patients with stable cognitive impairment or other forms of dementia. Assessment of the biomarkers yielded 89% sensitivity, 77% specificity, 73% positive predictive value and 91% negative predictive value, said the study, which used MRI and PET scans as part of the methodology.

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