Researchers have found that modified listeria bacteria can target primary and metastatic tumors in pancreatic cancer without harming healthy tissue. To improve the bacteria's targeting capability, the researchers used an antibody to attach the radioisotope rhenium-188 to the listeria. Tests on mice showed the radioactive treatment, without harming the livers and kidneys, led to a decrease in the number of metastatic tumors and weights of original tumors, according to the study published in the Proceedings of the National Academy of Sciences. A potential approach for clinical studies would be to remove the original tumor and eliminate the remaining lesions with radioactive listeria, a researcher said.
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