PET/CT imaging with carbon-11 acetate is useful for identification of lymphatic metastasis in patients making plans for or completing radical prostatectomy, according to a study published in The Journal of Nuclear Medicine that involved 107 prostate cancer patients who had intermediate- or high-risk localized disease. The study found that 11C-acetate-PET/CT detected pelvic lymph-node or distant metastasis in 36 patients, while histopathological results found lymph-node metastasis in 25 patients. Treatment-failure-free survival was poorer among those with positive PET scans, researchers said. The results show that "PET may have demonstrated nodal disease not removed surgically or identified pathologically," they wrote.
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