Researchers use 7 compounds to modify stem cells

07/19/2013 | Nature (free content)

A team of scientists was able to reprogram stem cells without altering the number of genes or risking dangerous mutations. Research published in the journal Science involved mixing seven small-molecule chemical compounds including DZNep, an inhibitor that reactivates developmental genes, to reprogram somatic cells to a pluripotent state. The researchers were able to create fully reprogrammed stem cells, which they called CiPS cells, and produce 0.2% of cells comparable to conventional techniques for producing induced pluripotent stem cells.

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