U.S. researchers looked at 90 3- to 6-year-olds who underwent dental rehabilitation and found that those who received prilocaine had substantially greater maximum methemoglobin levels than those given a combination of lidocaine and epinephrine. Patients who were not treated with any local anesthetic during the procedure reached the methemoglobin peak level in approximately half an hour, while the prilocaine and lidocaine/epinephrine groups took about an hour to reach maximum level, according to the study published in the journal Anesthesia Progress.
Study: Prilocaine raises methemoglobin levels in pediatric dental patients
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