Study: Amyloid buildup occurs early in patients with dementia

10/13/2011 | Irish Medical Times/Medical Publications Ltd.

Amyloid accumulation in patients with dementia seems to be an early occurrence, and as the disease progresses, clinical decline is linked more to neurodegeneration than amyloid buildup, according to a study published in the International Journal of Geriatric Psychiatry. The study, which used PIB-PET, found that amyloid levels are higher in patients with Alzheimer's disease and dementia with Lewy bodies than healthy participants and those with fronto-temporal dementia. PIB-PET imaging is a sensitive and specific marker for underlying amyloid buildup and can serve as a tool in evaluating the association between amyloid deposition, clinical symptoms and structural and functional changes in dementia, researchers said.

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