Median vaccination rates among Indian children ages 2 and younger in a rural community rose from 33% at baseline to 50% among those whose caregivers received mobile alerts with a compliance-linked incentive, compared with 40.1% of those whose caregivers received mobile alerts alone and 41.7% of those in the control group, according to a study in Pediatrics. Researchers also found that compliance-linked incentives were tied to a modest increase in vaccination timeliness.
The FDA placed a clinical trial for Solid Biosciences' Duchenne muscular dystrophy gene therapy on hold after the first patient in the trial had an adverse reaction. The patient experienced decreased platelet and red blood cell counts and showed evidence of complement activation, according to a Solid Biosciences statement.
Accenture polled 7,905 US adults and found that the use of wearables increased from 9% in 2014 to 33% this year, and the use of health care apps rose from 16% in 2014 to 46% in 2018. Researchers also found a slight increase in telemedicine use, from 21% last year to 25% this year, with 73% of respondents saying they would use the technology for after-hours care and 28% saying they would use it for their annual physical.
The FDA placed on hold a Phase I/II clinical study evaluating Advaxis' ADXS11-001, or axalimogene filolisbac, in combination with AstraZeneca's Imfinzi, or durvalumab, after a patient died of respiratory failure. The study is assessing the combination in patients with HPV-associated head and neck cancer, as well as patients with advanced, recurrent or refractory HPV-associated cervical cancer.
Clinical trials are scheduled to begin in Japan next year on an experimental whole-virus Ebola vaccine that has proven effective in monkeys. The vaccine is based on a form of the virus, developed at the University of Wisconsin School of Veterinary Medicine, that provokes an immune response but cannot replicate or infect other cells because the VP30 gene has been deleted.
Renowned physicist Stephen Hawking, who died early today, supported the use of animals in medical research. "The fuss over the use of animals in medical research is ridiculous," Hawking said in 1998. "Why is it worse to use animal experiments to save lives than to eat them, which the majority of the population are happy to do?"
A low dose of romidepsin, a drug already approved to treat cancer, restored social deficits in mouse models of autism with abnormally high levels of histone deacetylase 2, researchers reported in Nature Neuroscience. Autism spectrum disorders and cancers share genetic traits, and other cancer drugs might also affect ASD, the researchers said.
Officials at New York-based St. Peter's Surgery and Endoscopy Center reported that a malware attack on Jan. 8 may have exposed the records of 134,512 patients, who were notified of the incident on Feb. 28. The affected server contained patient names, diagnoses, insurance information, service dates, addresses and dates of birth, plus Medicare data and Social Security numbers for some patients.
A Spyglass Consulting Group survey found that extending EHR capabilities, customizing algorithms to hospital-based protocols, providing real-time access to data, and using data analytics to detect deteriorating conditions in patients are among the clinical surveillance technology tools hospitals and health systems are using to monitor high-risk patients. Hospital leaders cited the importance of these tools but reported being skeptical of technology vendors' claims related to predictive warnings and early detection for high-risk patients.
The President's Cancer Panel said in a report that stakeholders must work together to ensure cancer treatments are affordable and innovation is encouraged. The panel recommends pricing cancer drugs based on benefits, promoting the use of high-value drugs, discussing costs with patients, stimulating competition in the generic- and biosimilar-drug markets by reducing regulatory barriers, ensuring the FDA is equipped to do its job, and ensuring a stable, adequate NIH budget.