Researchers found that individuals with a blood urea nitrogen level of more than 25 mg/dL and an estimated glomerular filtration rate of less than 15 ml/min per 1.72 m2 had the highest risk for incident diabetes, compared with those who had lower BUN levels and normal eGFR levels. The findings in Kidney International, based on 1,337,452 individuals from the Department of Veterans Affairs database, revealed that an increased diabetes risk was tied to every 10 mg/dL increase in BUN level, but not to each 10 ml/min per 1.73 m2 increase in eGFR.
A study in Pediatric Diabetes showed that children with type 1 diabetes and asthma needed higher doses of insulin and had a higher body mass index standard deviation score and a lower height standard deviation score than those who did not have asthma. Researchers used a cohort of 51,926 children from the German/Austrian DPV database and found that while those with both type 1 diabetes and asthma had more severe hypoglycemia than those without asthma, there were no between-group differences in terms of A1C levels.
The FDA approved Sanofi's Admelog, or insulin lispro injection, as a treatment for adults with type 1 and type 2 diabetes and children with type 1 diabetes. Admelog has been approved as the first follow-on biologic version of Humalog, Eli Lilly and Co.'s fast-acting insulin.
Behavioral factors were seen as more important than biological factors as causes of obesity, and weight-loss drugs and surgery were viewed as less effective than lifestyle changes, according to a survey of bariatric specialists and primary care physicians published in Obesity Science & Practice. Researchers said physicians need more education because weight-loss surgery and medications can lead to additional weight loss beyond what is achieved through diet and exercise.
Researchers found that 12 of 123 patients with advanced-stage hepatocellular carcinoma with tumor portal vein thrombosis and elevated tumor marker alpha-fetoprotein levels had their AFP levels return to normal after undergoing yttrium-90 radioembolization and had a median overall survival of 23.9 months, while patients with the highest staging scores had overall survival of 3.9 months and those with the lowest scores had overall survival of 13.3 months. The findings in the Journal of Nuclear Medicine led researchers to conclude that Y90 radioembolization is safe and effective for advanced liver cancer patients with tumor portal vein thrombosis, with baseline liver function, AFP level and tumor size affecting overall survival outcomes.
Registered dietitian Tamara Duker Freuman said there are few legitimate reasons for a system-cleansing detox and the term itself does more harm than good because it is associated with punishing, restrictive diet regimens and eating disorders. Freuman said people should detox their relationship with food instead and improve their eating habits for the long term.
Registered dietitian Barbara Chin says it may not be necessary to eat before a light-intensity workout, but nutrition is vital before cardio activities such as running, cycling, swimming or strength training. RD Linzy Ziegelbaum says eating carbohydrates before a workout gives the body the glucose it needs for energy, and exercising in a fasting state can make people feel weak or lightheaded.
Sorghum is a nutritious, gluten-free cereal grain that can be used instead of pasta or rice, said registered dietitian nutritionist Valerie Agyeman. Stores sell sorghum in multiple forms, from whole or pearled to a flour, syrup and bran, and it can be cooked on the stovetop or in the oven, and frozen and reheated.
Eighty-three percent of youths allergic to at least two foods who received oral immunotherapy combined with omalizumab for 16 weeks passed the food challenge for two or more allergic foods, compared with only 33% who received oral immunotherapy with placebo, researchers reported in The Lancet Gastroenterology and Hepatology. The findings also showed a significantly lower median per-patient percentage of oral immunotherapy doses tied to adverse events among those who received omalizumab, while no serious adverse events were reported.
Abdominal obesity was associated with a higher risk of death within 3.4 years among patients with heart failure with preserved ejection fraction, while HFpEF patients with high BMIs had a lower risk of death in that time, according to a study in the Journal of the American College of Cardiology. Researcher Tetsuro Tsujimoto said diet and exercise to reduce abdominal obesity may be the most basic and important treatment for these patients.
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