Japanese researchers found that the synthetic vitamin A derivative acyclic retinoid destroyed EpCAM-positive hepatocellular cancer stem cells with elevated expression of the MYCN gene, while liver biopsies of 12 individuals whose HCC was removed through liver resection or ablation showed those who received 600 mg of acyclic retinoid daily for eight weeks had lower MYCN expression than those who only took 300 mg of the compound daily. The findings in the Proceedings in the National Academy of Sciences suggest that acyclic retinoid may curb HCC recurrence, researchers said.
An Express Scripts poll found that two-thirds of 800 adults with chronic diseases said they would be more likely to comply with their medication schedule if they received a reward for doing so, and that percentage rose to 88% among patients ages 18-34. Of all of those surveyed, 82% expressed a preference for personal monetary rewards, while 3% opted for charitable contributions.
The risk of diabetes may be predictable 20 years before it develops, giving people advance warning so they can take steps to prevent the disease, said registered dietitian Jae Berman. A physical exam and understanding measures such as body mass index and glucose are the first steps toward prevention, Berman said, followed by gradual changes toward a healthier diet and weight loss.
A study in Obesity revealed that almost 40% of men experienced weight stigma, with verbal mistreatment as its most common form and family members, peers and strangers as the most common sources. Researchers evaluated 1,513 men and found that those who reported experiencing weight stigma had higher body mass indexes, were more likely to have tried losing weight in the previous year, were younger and less likely to be married, compared with those who did not report weight stigma.
FDA Commissioner Scott Gottlieb told the Senate Appropriations Committee this week the agency is looking at whether consumers are being misled when plant-based products are described as milk or yogurt. Gottlieb said he wants to know whether consumers expect plant-based products to be nutritionally equal to dairy products.
A study in the American Journal of Cardiology found patients with obesity had a 40% greater risk of new-onset atrial fibrillation, compared to those without obesity. The findings, based on more than 67,000 patients with and without obesity, also showed higher likelihood of hypertension and diabetes among obese patients than among patients with healthy weight.
Two studies presented at the Experimental Biology annual meeting showed that individuals who consumed dark chocolate experienced a reduction in inflammation and stress levels and improvements in immunity, memory and mood. Consuming dark chocolate with a cacao concentration of at least 70% was associated with more positive health effects, researchers said.
All states saw improvements in the burden of cardiovascular disease from 1990 to 2016, but the improvements varied, a study in JAMA Cardiology showed. A dozen states saw increases in their total burden of CVD since 2010, however, and researchers said that may indicate the long-term decline in CVD may be ending and new clinical or public health interventions may be needed.
Draft recommendations from the US Preventive Services Task Force said there is sufficient evidence to support intimate partner violence screening for women of reproductive age. The task force found insufficient evidence to weigh the harms and benefits of screening in elderly and vulnerable adults for abuse.
High school students in the Spring Independent School District in Texas are helping create next year's lunch menu by taste-testing foods and providing feedback. "These taste-testing groups are open conversations to gather feedback and survey students about our food services as a department and the district as a whole," said district Child Nutrition Director and registered dietitian Shelly Copeland.