Tocagen's drug combination Toca 511 and Toca FC has received breakthrough status from the FDA as a treatment for patients with recurrent high-grade glioma. Results from an ongoing midstage clinical study are expected next year.
The administration's Affordable Care Act plans should prioritize fixing the individual insurance marketplace and put any changes to Medicaid on hold, AHIP President and CEO Marilyn Tavenner and American Hospital Association President Rick Pollack told the Nashville Health Care Council. Tavenner notes that with 70% of adults newly covered through ACA exchanges receiving subsidies, many would effectively lose insurance if subsidies were eliminated.
Researchers found that black stroke patients are 38% less likely to be given tissue plasminogen activator, which dissolves blood clots but must be administered soon after a stroke, than white patients, and Hispanics are 25% less likely to receive the treatment than whites, researchers report at the International Stroke Conference. The study also found disparities by gender, public vs. private insurance coverage and others, and treatment at urban hospitals, teaching hospitals and stroke centers was more likely to involve prompt administration of tPA.
Incyte and the University of Pennsylvania's Abramson Cancer Center have agreed to work together to study cancer immunotherapy and biology. In a multiyear collaboration, the cancer center will study the mechanisms of action of Incyte's therapeutics to develop clinical rationales for patient selection and combination therapy, and the partners will develop a bioinformatics program to advance novel immunotherapies.
Type 2 diabetes patients experienced increases in their 24-hour mean systolic and diastolic blood pressure and mean arterial pressure after six weeks of receiving the glucagon receptor antagonist LY2409021 once daily, compared with those on placebo, according to a study in Diabetes, Obesity and Metabolism. French researchers evaluated 270 patients and also found that those on LY2409021 had reduced A1C levels at week six and small but significant changes in aminotransferase and serum lipid levels.
A study in BMJ Open Diabetes Research & Care showed that individuals recently diagnosed with type 2 diabetes were at a fivefold increased odds of reporting a "poor" quality of life, a modest increase in the risk of experiencing psychological distress and reduced social contacts across four types of social contact than those without diabetes. Researchers used a cohort of 26,344 Australian adults without diabetes at baseline and found that the results persisted after adjusting for age, economic status, household income and marital status.
Researchers found that 56.2% of extremely obese women with cytomegalovirus infection had three or more risk factors for metabolic syndrome and higher levels of HDL cholesterol and lower triglyceride levels, compared with 82.6% of those without CMV infection. The findings in Obesity, based on 2,532 individuals ages between 20 and 49, revealed that 4.9% of normal-weight women with CMV had at least three MetS risk factors, compared with less than 1% of normal-weight women without CMV infection.
Providers were better able to correctly interpret patient directives when they included patient-made videos, compared with having just written documents, researchers reported in the Journal of Patient Safety. A survey with nine scenarios involving critically ill patients who had a Physician Orders for Life-Sustaining Treatment form or living will was sent to physicians, most of whom were not trained in evaluating end-of-life documents.
In a new position statement, the ANA has said that it opposes both capital punishment and nurse participation in capital punishment. "Participation in executions, either directly or indirectly, is viewed as contrary to the fundamental goals and ethical traditions of the nursing profession," according to the statement.
Data on almost 162,000 women ages 50 to 79 showed being overweight or obese did not increase mortality risks unless the extra weight was located around the waist, researchers wrote in the Journal of the American Geriatrics Society. Registered dietitian Sharon Zarabi said belly fat will increase the risk of death for anyone, and health professionals are putting more emphasis on looking at risks based on body composition rather than body mass index.
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