Sanofi's Genzyme unit agreed to pay as much as $300 million to acquire AstraZeneca's medullary thyroid carcinoma drug Caprelsa, or vandetanib. Under the terms of the deal, AstraZeneca is entitled to receive an upfront payment of $165 million and up to $135 million in potential milestone payments. The acquisition, which will be completed later this year, will strengthen Genzyme's endocrinology portfolio.
Postponing the final stage of EHR meaningful use would boost EHR adoption and promote advances in information exchange, said John Halamka, co-chair of the HIT Standards Committee, in an interview. Stages 1 and 2 have helped establish a foundation, but stage 3 includes standards that are not yet achievable, Halamka said. The certification rule for stage 3 would sow confusion, and more time is needed for the private sector to launch tools that meet stakeholders' business needs.
Ten percent of unexpected, serious adverse drug events are not reported to the FDA within the established 15-day window, according to a study published in JAMA Internal Medicine. That amounts to 160,383 adverse events, including 40,500 deaths, that were not reported in a timely manner. Kenneth Getz of the Center for the Study of Drug Development at Tufts University School of Medicine said some delays may involve the difficult process of verifying reports.
A study published in Pediatrics found that teens are more likely to smoke traditional or electronic cigarettes if someone else in the home does so, and they may be more likely to use traditional cigarettes. The report, based on 2,084 California teens, revealed that about 25% had used the electronic devices, and 10% had done so within the past 30 days. Twenty percent said they had used traditional cigarettes and 6% had done so within the past 30 days. One-third of teens who had smoked e-cigarettes also used traditional cigarettes, compared with 1% of those who'd never used e-cigarettes.
Registered dietitian Jamie Meeks said her job as director of Sports Nutrition with the New Orleans Saints and Pelicans is to plan, develop and manage the nutritional big picture for the football and basketball players. She counsels players on their diet goals, helps coordinate team meals and often drops by the team's cafeteria to see what players are choosing to eat.
Aromatase inhibitors and bisphosphonates each appear to improve outcomes among postmenopausal women with breast cancer, according to two studies in The Lancet, and combination treatment with the two complementary drugs could be even more effective. One study found that postmenopausal women who took aromatase inhibitors have a 40% lower risk of dying within 10 years, and recurrence was 30% lower than in those treated with tamoxifen. In a separate study, bisphosphonates were linked to 18% lower mortality.
Researchers evaluated 196 patients with and without nonalcoholic fatty liver disease and found that those with MRI-estimated proton density fat fraction values greater than the median value of 15.4% were more likely to have metabolic syndrome, independent of nonalcoholic steatohepatitis, compared with those whose MRI-PDFF values were below the median value. The study in Clinical Gastroenterology and Hepatology also showed that NAFLD patients with high MRI-PDFF values had an increased likelihood of having abdominal obesity and higher levels of high-density cholesterol, triglycerides and fasting glucose.
An imaging study in JAMA Neurology found that insulin resistance in individuals at high risk of developing Alzheimer's disease is tied to reduced regional cerebral glucose metabolism. Lower glucose metabolism in the left medial temporal lobe was strongly correlated with poor performance on immediate memory and delayed memory tasks, researchers found.
A white paper from the Health IT Now Coalition and the Center for Data Innovation recommends regulatory changes to promote the success of the Precision Medicine Initiative and other Big Data genomics research. The report says the U.S. should help patients and providers share health data, promote conversations with patients and the private sector about genomic research and change HIPAA regulations to base penalties on harm done rather than the number of records breached.
Study data show in the 2012-13 school year it was just about as likely that students at racially diverse schools would get fruits, vegetables and whole grains each day as it was for students at predominantly white schools. A nutrition gap seen in 2010-11 began to close as schools started implementing new nutrition standards, researchers say.