Researchers are closer to being able to produce a "limitless supply of blood" in part through the identification of key transcription factors that can be used to convert induced pluripotent stem cells and embryonic stem cells into blood stem cells, according to two studies in the journal Nature. Study teams developed methods shown to work in the laboratory and in mouse models.
To coincide with the observance of National Hepatitis C Testing Day today, the American College of Physicians and the American Academy of HIV Medicine's Institute for Hepatitis C have produced a resource for clinicians who screen for the virus. The Guide to Hepatitis C Testing includes information on reimbursements and who should be screened.
Breakthrough therapy status has been granted by the FDA to GlycoMimetics' GMI-1271 as a treatment for adult patients with relapsed/refractory acute myeloid leukemia. The company has an ongoing midstage trial to evaluate the combination treatment of GMI-1271 with chemotherapy in AML patients.
Bayer's new-drug application for its experimental drug candidate copanlisib, developed for the treatment of recurrent or persistent follicular lymphoma, was given priority review status by the FDA. Data from a midstage trial indicated positive results in 60% of the participants.
An expert committee report from the National Academies of Sciences, Engineering, and Medicine on the role of the US in global health was unveiled at a recent briefing as a guide for the Trump administration on vital global health concerns. The report highlights four key priority areas -- global health security; HIV, tuberculosis and malaria; women and children; and cardiovascular disease and cancer -- and also noted challenges such as shortages in countermeasures and the need for better coordination with numerous organizations.
Keytruda, or pembrolizumab, has received accelerated approval from the FDA as a treatment for children and adults with refractory classical Hodgkin lymphoma or those who have experienced relapses after at least three previous therapies. An added warning and precaution highlights the risk of complications for patients who received allogenic hematopoietic stem cell transplants after taking pembrolizumab.
A mouse study of a method for transplanting cells into a liver using irreversible electroporation found it was associated with increased stem cell survival and potential restoration of the failing organ. Researchers from the University of California at San Francisco used electrical pulses to kill cells in a section of the diseased organ, creating room for the implanted cells while maintaining the extracellular matrix, according to the study in the journal Bio Techniques.
Tanzania is beginning a public health mission to raise awareness about Ebola virus risks and safety along the nation's border with the Democratic Republic of Congo.
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