A pair of collaborations was launched by Stanford University spinout Forty Seven to evaluate its drug candidate Hu5F9-G4 in combination with Merck's Bavencio, or avelumab, in patients with ovarian cancer, and Genentech's Tecentriq, or atezolizumab, in patients with acute myeloid leukemia and with urothelial cancer. Values of both deals were not disclosed.
Los Angeles County has reported a case of sexually transmitted Zika infection in a woman whose partner had visited Mexico, according to the CDC. A study in the journal PLOS Pathogens found that a lack of surveillance data makes estimating the risk of sexual transmission difficult for Zika.
CEO Matthew Kapusta of uniQure said his firm plans to sponsor a pivotal study of its hemophilia B gene therapy candidate AMT-061 this year. The study is scheduled to begin in the third quarter.
A Phase I study found that Ziopharm Oncology's therapy candidate Ad-RTS-hIL-12 and veledimex was safe to use in treating recurrent glioblastoma. Ziopharm is also collaborating with Intrexon for the development of chimeric antigen receptor T-cell therapies and conducting a Phase I study at MD Anderson Cancer Center of a CD33-specific CAR T-cell therapy candidate for acute myeloid leukemia.
A deal to acquire Fast Track Diagnostics for undisclosed terms was completed by Siemens Healthineers. Fast Track, which makes syndromic panels and infectious disease detection tests with sites in Malta, India and Luxembourg, will be integrated into the Siemens Healthineers business and will maintain its brand name.
Plasmodium vivax enters blood cells by attaching itself to a protein that delivers iron to young blood cells, according to a study led by a team of scientists with Australia's Walter and Eliza Hall Institute of Medical Research. The findings were published in the journal Science.
A new star-shaped pill in the early stages of being developed could reduce the number of times people with HIV need to take their medications to once a week, with the pill containing "multiple drug-polymer combinations and slowly [releasing] drugs over the course of seven days," said researcher Dr. Giovanni Traverso. The study was published in the journal Nature Communications.
A study in JAMA Ophthalmology found that corneal donor tissue can be safely stored for 11 days before transplantation. The findings were based on data for Descemet stripping automated endothelial keratoplasty procedures for 1,330 eyes.
Placental tissue donations can be processed for use in treating conditions such as burns, surgical wounds and diabetic ulcers, writes Sarah Gray of the American Association of Tissue Banks. Two grafts from the donation were used to promote healing after surgery for a 5-year-old boy with osteosarcoma, and parents interested in donation can begin by asking a local organ procurement organization for their recommendations or using the AATB's Accredited Bank Search, Gray writes.
Stem cell researchers at Indiana University School of Medicine cultivated skin with hair follicles from pluripotent stem cells of mice, according to a paper in the journal Cell Reports. "The skin is a complex organ that has been difficult to fully re-create and maintain in culture for research purposes," researcher and surgery professor Karl Koehler said.
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