Liquid chromatography used with tandem mass spectrometry is an important technique in many laboratories, but the process of beginning to use it comes with challenges. These challenges include assuring that the system is working properly, and system suitability tests are a key part of labs' in-house early detection systems.
At least 90 cases of Ebola virus infection, including 49 deaths, have been reported in the Democratic Republic of Congo, according to health officials. More than 1,500 people have been identified as potential contacts, but "we're at a critical moment where we are not yet sure we have all the chains of transmission identified," said Tarik Jasarevic of the World Health Organization.
A study of ibrutinib, or Imbruvica, as a first-line treatment for 30 patients with Waldenstrom macroglobulinemia who carried MYD88 mutations found declines in immunoglobulin M levels and bone marrow involvement and increases in median hemoglobin levels. The findings were reported in the Journal of Clinical Oncology.
The drug candidate CPI-613 from Rafael Pharmaceuticals has received an orphan drug designation from the FDA as a treatment for peripheral T-cell lymphoma. An early-stage trial is being conducted for the lipoic acid analogue among patients with T-cell lymphoma.
Scripps Research Institute scientists found that the enzyme YRSACT, which is known to play a role in decoding DNA, appears to increase platelet production in tests of animals, according to a study in the journal Proceedings of the National Academy of Sciences. Researchers say YRSACT works by boosting production of platelet-producing megakaryocytes, and the findings suggest a new drug target to treat thrombocytopenia.
Health officials in California reported in the journal Emerging Infectious Diseases that the state had 588 cases of travel-related Zika virus infection from November 2015 to September 2017, and 64% of the probable viremia cases involved people living in counties where Aedes mosquitoes have been found. Meanwhile, the National Institute of Allergy and Infectious Diseases has begun a trial of an experimental live attenuated Zika vaccine in 28 healthy volunteers.
A late-stage study in The New England Journal of Medicine found 83% of 40 adults with multidrug-resistant HIV-1 infection who were treated with ibalizumab, or Trogarzo, experienced reductions in viral load.
Methicillin-resistant Staphylococcus aureus colonization is associated with increased risk of subsequent infection during and after hospitalization, according to a study in the journal Clinical Infectious Diseases of Department of Veterans Affairs data for 985,626 hospital admissions. "Hospitalized patients who are colonized with MRSA, regardless of whether they were colonized on admission or acquired it during their inpatient stay, are at high risk for MRSA infection," VA epidemiology researcher Richard Nelson said.
Health officials in the Democratic Republic of Congo reported five new confirmed cases of Ebola virus infection among four health care workers and a former patient at a center in Mangina. World Health Organization Director-General Tedros Adhanom Ghebreyesus said cases have been confirmed in a total of seven health care workers.
Mustang Bio and St. Jude Children's Research Hospital will work together to develop an ex vivo lentiviral gene therapy for severe combined immunodeficiency, or "bubble boy" disease. The collaboration will focus on completing their Phase I/II clinical trials, one of which involves patients under the age of 2, with promising responses from eight patients who already received the treatment.
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