Italian investigators found that adding ribavirin to direct-acting antiviral therapies to treat hepatitis C virus infections with mixed cryoglobulinemia increased immunological response and reduced serum cryocrit among patients achieving sustained virologic response at 12 weeks. The research was published in the journal Archives of Virology.
A paper in the journal The Annals of Thoracic Surgery describes how Daxor's BVA-100 blood volume analyzer is capable of illuminating intravascular fluid derangements missed by standard tests and has 98% accuracy in quantifying whole blood and red blood cell volume.
Researchers analyzed data for 2,951 orthopedic surgery patients and found that median hospital stays and 30-day readmission rates fell after introduction of a comprehensive patient blood management program. Blood transfusion use dropped, and trigger hemoglobin levels decreased from 7.8±1.0 to 6.9±1.1 g/dL.
The Malaria Summit London, co-hosted by the UK, Rwanda and Swaziland, has resulted in almost $4 billion in new pledges to support malaria prevention and research. At the 7th Multilateral Initiative on Malaria Pan African Malaria Conference in Senegal, researchers warned that famine and conflict threaten the past decade's progress against malaria.
A woman in her 60s and a man in his 80s with severe neovascular age-related macular degeneration experienced improved sight after receiving implants of stem cell-derived retinal pigment epithelium cells. "This study represents real progress in regenerative medicine and opens the door to new treatment options for people with age-related macular degeneration," said researcher Pete Coffey of University College London.
At a Donate Life Month celebration, Sue Landacre, a registered nurse and clinical coordinator at United Hospital Center in Bridgeport, W.Va., shared the story of the death of her 13-year-old son Jake 12 years ago and her decision to donate his eyes and tissue. "It's a rewarding thing. It's the last gift they can give and the last gift you can give for them," Landacre said.
Alberta Health officials said donor registrations rose by a factor of 10 after the crash of a bus carrying a youth hockey team in Canada that killed 16 people. Over five days, the Alberta Organ and Tissue Donation Registry logged 12,704 new registrations.
A single injection of two genetically modified, broadly neutralizing antibodies protected rhesus monkeys from infection with simian-human immunodeficiency virus for a median of 20 weeks, researchers reported in Nature Medicine. A single mutation introduced into each of two antibodies extended the antibodies' survival in the monkeys' bloodstreams and protected the monkeys for longer than the unmodified antibodies, both when administered alone and in combination.
Researchers surveyed 86 labs worldwide and found that although 93% used massively parallel sequencing platforms to identify variants in breast and ovarian cancer genes, 27 of the respondents mostly used Sanger sequencing to confirm genetic variants identified through other methods while six used Sanger as their only method. "Global best-practice guidelines for BRCA testing are needed to ensure consistency in testing for patients, regardless of where they obtain their testing," said study author Amanda Toland.
A vaccine for the Zaire strain of the Ebola virus developed by Merck resulted in high and stable antibody levels two years after vaccination as part of a trial carried out in Guinea. The findings were reported in The Lancet Infectious Diseases.
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