Lab Sciences
Top stories summarized by our editors
5/8/2018

A group of international researchers used mouse models to study the role of the Y chromosome gene UTY in protecting against the development of acute myeloid leukemia. The findings were reported online in the journal Nature Genetics.

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Nature Genetics
5/8/2018

The Clarity Clostridium difficile toxins A/B assay by Singulex outperformed other currently used diagnostic tests by rapidly detecting toxins at 100 times lower concentrations, a study found. Singulex expects FDA registration for the test by the end of the year.

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Singulex, FDA
5/8/2018

A study in the journal PLOS Pathogens estimated that 84% of cases of dengue fever are the result of transmission from asymptomatic individuals. Researchers from the University of Notre Dame employed mathematical modeling based on demographics and disease characteristics and also found that 1% of transmissions are attributable to people whose infections have been clinically detected.

5/8/2018

Research seeking to determine why some patients with relapsed/refractory chronic lymphocytic leukemia do not respond to chimeric antigen receptor T-cell therapy has yielded data that may give drug developers and scientists a clue, according to findings published in the journal Nature Medicine. "Our biomarker, which is defined as CD27-positive, CD45RO-negative CD8+ T cells in pre-manufactured T cells, may help in patient selection," said senior study author Joseph Melenhorst.

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Nature Medicine
5/8/2018

A filing has been submitted by British biotech firm Autolus for an initial public offering in the US that could be worth $100 million. The proceeds from the IPO will advance research to make stem cell therapies safer by developing safety switches for the company's treatments.

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Reuters, Endpoints News
5/8/2018

Patents for Gilead Sciences' hepatitis C drug sofosbuvir and HIV medication Truvada were rejected by Brazil and Europe, respectively, after patent challenges by the nonprofit Initiative for Medicines, Access & Knowledge and its partners. Two challenges brought by the nonprofit against Gilead for sofosbuvir in the US were blocked by the US Patent Trial and Appeal Board.

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PharmaBiz (India)
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Gilead Sciences, Brazil, Europe, Truvada
5/7/2018

A study in the journal Cell describes how NIH researchers studied the cellular mechanisms that aid in the hibernation of the 13-lined ground squirrel. "By understanding the biology of cold adaptation in hibernation, we may be able to improve and broaden the applications of induced hypothermia in the future, and perhaps prolong the viability of organs prior to transplantation," said study co-author Wei Li of the National Eye Institute's Retinal Neurophysiology Section.

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Wei Li, National Eye Institute, NIH
5/7/2018

A portable diagnostic test that uses CRISPR-Cas13-based technology was capable of detecting the Zika and dengue viruses at levels of 1 copy/mcL, according to a study in the journal Science.

5/4/2018

A study of 16 women with HIV and their infants suggests that the viral variants that are passed to infants are more resistant to the mother's antibodies in the blood. Researchers said in the journal PLOS Pathogens that a vaccine that increases maternal immune response could decrease already low rates of transmission with antiretroviral therapy.

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MD Magazine online
5/4/2018

The Links Foundation has provided St. Jude Children's Research Hospital in Memphis, Tenn., with a $1 million grant to advance research about sickle cell disease. A portion of the donation will finance the creation of an app to help educate patients.