Injecting Botulinum toxin A into the pectoralis major muscle can reduce postoperative pain in women who undergo silicone breast reconstruction after mastectomy, according to a small clinical trial at Southwest Washington Medical Center in Vancouver, testing an off-label use of the drug. Women who received Botox injections reported less postoperative pain and took fewer doses of narcotics and muscle relaxants seven to 45 days after surgery than women who received placebo injections.

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