PET imaging with 18F-fluoroestradiol showed that estrogen-receptor-blocking drugs such as tamoxifen and fulvestrant performed better than estrogen-eliminating drugs in stopping estrogen receptor in cancer cells of patients with breast cancer metastasis to the bones, according to a study published in Clinical Cancer Research. Tamoxifen also proved to be more effective than fulvestrant in hindering estrogen, according to the study. "Our findings support the ability of FES-PET to visualize the in vivo activity of endocrine therapy," the researchers said.

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