10/14/2011

Amyloid accumulation in patients with dementia seems to be an early occurrence, and as the disease progresses, clinical decline is linked more to neurodegeneration than amyloid buildup, according to a study published in the International Journal of Geriatric Psychiatry. The study, which used PIB-PET, found that amyloid levels are higher in patients with Alzheimer's disease and dementia with Lewy bodies than healthy participants and those with fronto-temporal dementia. PIB-PET imaging is a sensitive and specific marker for underlying amyloid buildup and can serve as a tool in evaluating the association between amyloid deposition, clinical symptoms and structural and functional changes in dementia, researchers said.

Related Summaries