A midstage trial showed that Abbott Laboratories' protease inhibitor ABT-450, in combination with polymerase inhibitor ABT-333 and existing drug ribavirin, suppressed the hepatitis C virus 12 weeks after treatment ended in more than 90% of treatment-naive patients and 47% of patients who didn't respond to prior treatment. In another Phase II study, 10 of 11 patients who received ABT-450 along with Abbott's polymerase inhibitor ABT-072 and ribavirin showed a sustained virologic response 24 weeks after treatment ended. Abbott hopes to take forward some combination of the drugs used in the studies into Phase III testing next year.

Related Summaries