Treatment with high-dose prednisolone for two weeks cured 18 of 30 babies diagnosed with refractory infantile spasms in a study presented at the American Epilepsy Society's annual meeting. Five of the 12 who did not respond to prednisolone were cured after a subsequent two-week treatment with intramuscular adrenocorticotropic hormone. Though a larger, randomized study is needed to confirm the results, high-dose prednisolone may be a safe first-line alternative to ACTH therapy, the lead researcher said.

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