Researchers analyzed data from two U.K. health databases and found that patients who simultaneously took a nonsteroidal anti-inflammatory drug and a dual antihypertensive regimen consisting of a diuretic and either an ACE inhibitor or an angiotensin receptor blocker were 31% more likely to develop acute kidney injury than those who took the blood pressure drugs alone. The risk was highest during the first 30 days of treatment, according to the study published online in BMJ.

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