Researchers are studying the effects of cancer drugs on the brain in an effort to understand and prevent cognitive decline, or "chemo brain." Mouse studies have shown exercise and the antidepressant fluoxetine might slow or reverse cognitive decline, but the studies do not reflect real-world chemotherapy regimens, writes Ellen Walker, a professor of pharmaceutical sciences at Temple University who is researching chemo brain. The scientific community needs to develop more informative models and set standards for cognitive testing to identify at-risk patients and develop preventive therapies, Walker writes.

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