In-office injections of soft-tissue fillers rarely result in serious adverse reactions, according to a meta-analysis published in JAMA Facial Plastic Surgery. The study authors reviewed 2,089 in-office procedures between 2007 and 2011 involving hyaluronic acid, poly-L-lactic acid or calcium hydroxylapatite and found only 14 reports of complications, including nodules or granulomas, cellulitis and skin necrosis. Hyaluronic acid had the best safety profile, followed by poly-L-lactic acid and calcium hydroxylapatite.

Related Summaries