Researchers collaborating on the NIH's Cancer Genome Atlas project are discovering similar mutations in different cancers, which could change how cancer is treated. For example, researchers report commonalities in certain types of breast, ovarian and endometrial cancers, as well as a similar mutation in some endometrial and colon cancers that disables a DNA repair mechanism. In another arm of the project, researchers studied 200 acute myeloid leukemias and identified common genetic malfunctions that will guide treatment decisions.

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