UK researchers found every 5mg per day increase of prednisolone, a glucocorticoid, increased the risk of developing type 2 diabetes by 25% to 30%, but there was no association between a dose of less than 5mg and diabetes risk, compared to no treatment. The findings in the journal Arthritis and Rheumatology, based on 32,600 US and UK patients with rheumatoid arthritis, showed that the diabetes risk was only affected by the prednisolone dose in the most recent six months.
The FDA approved Oramed Pharmaceuticals' investigational new drug application for ORMD-0801, an oral insulin capsule for patients with diabetes. The company plans to begin a Phase II clinical trial of the drug for type 2 diabetes in the U.S.
Data on 559 teens ages 14 to 18 showed those who had a low-fiber diet had bigger waistlines and greater levels of inflammatory factors in the blood, increasing their risk of diabetes and cardiovascular disease. The findings appear in the Journal of Clinical Endocrinology and Metabolism.
A study in JAMA found that daily low-dose aspirin intake was linked to a higher risk of major cerebral or gastrointestinal bleeding and that diabetes patients had a 36% increased risk of bleeding, regardless of aspirin use. "Our study shows, for the first time to our knowledge, that aspirin therapy only marginally increases the risk of bleeding in individuals with diabetes. These results can represent indirect evidence that the efficacy of aspirin in suppressing platelet function is reduced in this population," researchers said.
Omega-3 fatty acids help activate insulin signaling cascade, a process that boosts the body's energy expenditure, experts reported in Nutrition and Metabolism. Researchers said that a diet high in omega-3 intake helps improve carbohydrate and fat metabolism, which may reduce the risks of type 2 diabetes and heart disease.