Ventilator-perfusion SPECT imaging with a diagnostic limit of 1 segmental or 2 subsegmental mismatches is the best way to diagnose or rule out acute pulmonary embolism, according to a study published in The Journal of Nuclear Medicine. It was the second in a three-part series of research designed to validate V/Q SPECT for routine clinical use. Researchers said the next and last trial "will be a large management outcome study including V/Q SPECT in the diagnostic algorithm, in which patients with a negative diagnostic work-up would be left untreated and followed up over time."

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