Combining clopidogrel and aspirin can lower the risk of a second stroke by almost one third compared with aspirin alone, according to a study in the New England Journal of Medicine. Researchers tracked more than 5,000 patients who survived a stroke or mini-stroke and found that 11.7% of those who took aspirin alone suffered another stroke compared with 8.2% of those who received the clopidogrel-aspirin combination. "Giving two drugs that block platelets works a lot better than aspirin alone in people who have had a minor stroke or TIA," a researcher said. An expert not involved in the study said providers have been moving away from the combination due to risk of serious bleeding.

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