An older, cheaper regimen that combines methotrexate, sulfasalazine and hydroxychloroquine is as effective as the costlier combination of methotrexate and etanercept in treating rheumatoid arthritis patients who don't respond to methotrexate alone, a study found. U.S. researchers followed 353 patients and found no difference in improvements between the two groups. The study appeared online in the New England Journal of Medicine.

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