A team of scientists was able to create induced pluripotent stem cells without altering the number of genes or risking mutations. The method uses seven small-molecule chemical compounds including DZNep, an inhibitor that reactivates developmental genes, to reprogram somatic cells to a pluripotent state. The researchers reported in the journal Science that they were able to create fully reprogrammed stem cells, which they called CiPS cells, and produce a conversion rate of 0.2%, which was comparable to conventional techniques for iPS cells.

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