Most clients of New York dermatologist Dr. Macrene Alexiades-Armenakas aren't after a 20-something face: They are older, career-focused women who want to appear energetic and serious. That, says one of her longtime clients, Melanie Kusin, vice chairman at Korn/Ferry International, means treatments that aim for one thing: to be "suspended at the 45 to 55 range."

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