Canadian researchers found that F-18-DCFPyL PSMA PET/CT resulted in treatment intent and disease staging changes in 65.5% of individuals with biochemically recurrent prostate cancer, most of whom had upstaged disease. The approach, described in the Journal of Nuclear Medicine, also led to management plan changes in 87% of patients, and no serious adverse events were reported.
A highly specialized technologies guidance has been released by the UK's National Institute for Health and Care Excellence endorsing Akcea Therapeutics' hereditary transthyretin-related amyloidosis therapy Tegsedi, or inotersen, for National Health Service use in England.
A study in JAMA Internal Medicine found CMS policy changes resulted in 44.1% of teaching hospitals and 43.7% of rural hospitals receiving a lower readmission penalty this year compared with last year. The changes were made in response to complaints by safety-net hospitals that their penalties were unfair because they had a more complex mix of patients.
Ten babies with X-linked severe combined immunodeficiency, or "bubble boy" disease, who received a gene therapy that replaces a defective gene variant soon after birth were successfully treated and had normal growth and development without complications or side effects. The findings in The New England Journal of Medicine also showed healthy immune systems and vaccine response among treated infants, but more studies are needed to identify any long-term issues.
Two studies in The Lancet Infectious Diseases analyzed genes of Ebola virus strains from the Democratic Republic of Congo's ninth and 10th outbreaks of the virus. The study team said virus samples from the current outbreak are not from the Tumba strain and are susceptible to monoclonal antibody treatments.
A study in Diabetes Care found that hyperuricemia, or serum uric acid levels of 6.8 mg/dL or higher, was associated with increased risk of cardiovascular disease, hypertension and kidney disease among teens with type 2 diabetes. Researchers analyzed data for 539 patients with a mean age of 13.9 in the Treatment Options for Type 2 Diabetes in Adolescents and Youth trial.
The 360 diabetes patients, average age of 58, who participated in artificial intelligence-based chronic disease management startup Lark Health's Diabetes Prevention Program experienced an average of body weight reduction of 4.3%. The AI-based text messaging program -- which advises patients on physical fitness, nutrition, sleep habits and stress management -- earned a Full Recognition status from the CDC, which "allows for true scalability and access and because as an AI solution, we can pass along our tech savings to our partners," said Lark Health CEO Julia Hu.
The behavioral and medical effects of excessive alcohol consumption were detailed by clinical social worker Kendra McKee and addiction counselor Bill Milchak in this Alcohol Awareness Month interview. The Pennsylvania professionals discussed such topics as the misconception that alcohol use disorder is not a disease.
Post-traumatic stress disorder is prevalent in refugees, along with "very high rates of depression," says associate social work professor Diane Mitschke of the University of Texas at Arlington. Kazito Kalima, a refugee from Rwanda who founded an Indianapolis nonprofit that helps put refugees in touch with mental health resources, says his trauma showed up as physical symptoms, a manifestation common among people from cultures where mental health issues equated with stigma.
Social worker Juan Vasquez wanted to spare students at Mayo High School in Rochester, Minn., the stigma he'd suffered as an impoverished youngster, so he engineered the conversion of a cramped resource room into a wide-open gathering place. Students helped raise the money for the S.O.S. Room and run it as a service and social club.