EpiPens and other epinephrine autoinjectors might continue to work months after their labeled expiration date, researchers report in the Journal of Allergy and Clinical Immunology: In Practice, and the finding could save patients money. Autoinjectors contained 100% of the original dose six months after expiration and 95% of the original does one year after expiration.
Only 11% of children and adults with rare and debilitating pantothenate kinase-associated neurodegeneration who received the iron chelator drug deferiprone needed additional dystonia treatment, compared with 21% of those who took placebo, and although both groups had similar disease progression, those with later-onset atypical PKAN who were given deferiprone had nearly 50% reduced disease progression as those in the placebo group, according to a study in The Lancet Neurology. The findings suggest that iron chelators may be useful in treating Alzheimer's disease, multiple sclerosis and Parkinson's disease, researchers said.
Progenics Pharmaceuticals has begun dosing the first patient in a midstage trial evaluating the safety and efficacy of Progenics' I-131 1095 in combination with Astellas Pharma and Pfizer's Xtandi, or enzalutamide, to treat patients with PSMA-avid metastatic castration-resistant prostate cancer, compared with Xtandi alone.
The use of muscle-pump activators instead of compression stockings was associated with shorter hospital stays and better short-term outcomes for patients who had a kidney transplant or a simultaneous pancreas and kidney transplant, researchers reported at the American Transplant Congress. Dr. Alp Sener said MPAs are the size of a pen and can stimulate the leg equal to walking several miles per day.
A study in Pediatric Emergency Care showed that the rate of marijuana ingestions among children younger than 6 rose 27% annually between 2009, when marijuana legalization expanded, and 2017, and states with legal marijuana accounted for more than 70% of pediatric marijuana ingestions. Researchers also found that 54.6% of youths who ingested marijuana required hospital-based care, 7.5% of whom needed critical care.
Advanced ICU Care CEO Lou Silverman said telehealth has an important and growing role in health care and the delineation between in-person care and virtual care is disappearing, even in critical care settings. "The greatest successes occur when workflows and patient engagement are built around the unique attributes of a specific telemedicine specialty rather than focused on importing bedside traditions into the telemedicine environment," Silverman said.
A study in the Journal of General Internal Medicine based on EHR data from 170,332 encounters and interviews with 40 physicians found that variations in clinical documentation in EHRs could result in patient harm and clinical inefficiencies. Researchers suggest conducting user training during the implementation of EHR systems and setting up practice meetings for standardized documentation.
A session at the recent meeting of the American Society of Safety Professionals focused on how to enhance safety during the handling or moving of patients and how to decrease the risk for injuries and musculoskeletal disorders among health care professionals, including nurses. The speakers recommended the establishment of safe patient handling and mobility programs following principles set forth by the ANA.
Two immunocompromised patients contracted severe antibiotic-resistant infections resulting in one death after receiving fecal transplants, according to the FDA. The agency said it is stopping trials of fecal transplants until researchers are able to put in place safety processes to screen stool donations.
A trauma-informed approach can help libraries treat patrons with mental health needs, substance abuse issues and other challenges respectfully and constructively, says Caroline Sharkey of the University of Georgia School of Social Work. "[W]e offer specific approaches on how to de-escalate a situation through a trauma-informed lens," says licensed clinical social worker Elissa Hardy of the Denver Public Library.