Cytiva will help optimize antibody therapy manufacturing processes for UK-based Lakes BioScience. The agreement is expected to produce 250 new jobs at a $484 million factory to be built in Cumbria, England.
Process control systems designed for a fixed number of unit operations in a static facility are not good fits for modern, flexible biopharmaceutical manufacturing strategies, and more advanced control systems that can be deployed at larger scales are needed, according to a study in Systems Microbiology and Biomanufacturing. Artificial intelligence is likely to be a critical component of real-time process variable control systems and strategies that consider economic and environmental objectives, says study co-author Ganti Murthy, a professor at the Indian Institute of Technology.
Thermo Fisher is investing $154 million in its Patheon fill-and-finish facility in Greenville, N.C., boosting capacity for pre-filled syringes, solid dose continuous manufacturing, and sterile liquids and lyophilization. The facility is likely to add 290 new jobs.
Construction is underway on Grand River Aseptic Manufacturing's 18,000-square-foot fill-and-finish facility in Grand Rapids, Mich. CRB Consulting Engineers, Midwest Cleanroom Associates, MJM Process and Rockwell Automation are leading the project.
Adopting the right tools and change management strategies will help pharmaceutical manufacturers with the transition to Pharma 4.0, writes Perry Zalevsky, a senior director at IT consulting company Aveva Group. Plan big but start small, match the technology to the culture, define goals, and focus on people and their capabilities, Zalevsky writes.
Reflex testing approaches for urinalysis can increase efficiency and, if used along with well-designed electronic order options and clinical decision-support systems, can help labs optimize test use. It can also result in faster turnaround times and lower costs for both labor and reagents.
The World Health Organization has declared an end to the Marburg virus outbreak in Guinea with no new cases reported in the weeks following the nation's first case. "Today we can point to the growing expertise in outbreak response in Guinea and the region that has saved lives, contained and averted a spill-over of the Marburg virus," said Matshidiso Moeti, the WHO's regional director for Africa.
Researchers find that measuring prehospital glial fibrillary acidic protein plasma samples through ultra-sensitive single-molecule array can be a diagnostic tool in differentiating acute cerebral ischemia and hemorrhagic stroke in patients. "With serial measurement GFAP has potential to improve future prehospital stroke diagnostics," the researchers said.
Researchers from University of California, Cedars Sinai Medical Center, the University of Utah and research institutions in China have developed a blood test that can detect and identify placenta accreta spectrum disorder by using NanoVelcro Chip technology that detects placenta cells in maternal blood samples. The test requires 2mL of blood and can produce result in less than 24 hours.
Inflammatory bowel disease development among children with juvenile idiopathic arthritis was linked to enthesitis-related arthritis, as well as to family history of autoimmune disease, researchers reported in the journal Rheumatology. The findings, based on data involving 8,942 patients with juvenile idiopathic arthritis, also observed an increased IBD incidence in those who were exposed to etanercept therapy, with or without the use of methotrexate.
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