Scientists from Harvard University's Wyss Institute are developing vascularized kidney organoids to allow for more accurate modeling of mature kidney functions, according to a study in the journal Nature Methods. The study team said that culturing the organoids in an environment of fluid flow promoted the development of vasculature.
Chain of custody is a key component of legal urine drug testing because the results of the test could be presented as court evidence. While chain of custody is not used in medical alcohol testing, the results are sometimes presented as evidence in impaired-driving cases. "In such situations, a laboratory scientist should simply confirm that the specimen was not collected following chain of custody and let the prosecution pick up the battle," writes pathology and laboratory medicine professor Amitava Dasgupta.
Treating mosquitoes with diet drugs led to loss of appetite for human blood, according to a study in the journal Cell. The tests were done on female Aedes aegypti mosquitoes, which can carry the dengue, yellow fever and Zika viruses.
In a Phase II clinical trial of Catalyst Biosciences' MarzAA, or factor VIIa variant marzeptacog alfa (activated), seven patients with hemophilia A or B with inhibitors have completed dosing. Two other patients are being dosed while more are being screened, and enrollment has been completed.
A study in the journal Bone Marrow Transplantation found that two hours of cryotherapy before receiving melphalan as part of a conditioning regimen before autologous hematopoietic stem cell transplantation was comparable to seven hours of cryotherapy for the prevention of oral mucositis. The findings were based on data for 94 patients with multiple myeloma.
A breakthrough blood test involving blood protein classification and a machine learning algorithm to determine preclinical Alzheimer's disease biomarkers yielded 90% accuracy in matching PET scan results, as well as identified 10 protein features, two of which were previously determined as likely biomarkers. The technique, described in Science Advances, may be used to detect early Alzheimer's symptoms, but more studies are needed before using it for diagnosis, researchers said.
The FDA has approved Grifols' Procleix assay to detect ribosomal RNA from four species of the malaria-like parasite Babesia. Tick bites and donated blood can be sources of Babesia transmission.
More than a year and a half later, the first US patients treated with a gene-editing therapy do not show signs of disease improvement. The trial's aim was to improve levels of certain sugars that build up and cause damage to bones and other organs in patients with Hurler syndrome; however, the sugar levels remained effectively the same despite replacement of defective genes.
China's National Health Commission cautioned hospitals against using a batch of plasma treatments from the state-owned Shanghai Xinxing Pharmaceutical Company after HIV was found. The batch included 12,229 50-milliliter bottles.