Researchers examined data from 7,603 participants and found that a higher HDL-mediated cholesterol efflux capacity, as estimated by nuclear magnetic resonance spectroscopy, correlated with a reduced risk for incident coronary heart disease. The findings align with published associations using in vitro cell diagnostics.
Bayer will acquire the remaining 59.2% of privately held shares from BlueRock Therapeutics and will make an upfront cash payment of $240 million plus milestones of up to $360 million. The acquisition will grant Bayer full rights to BlueRock's CELL+GENE platform.
San Diego-based Organovo has run out of funds to continue its research for the development of 3-D investigational tissue patches designed to help patients on standby for an organ transplant. A regulatory filing indicates the company has laid off 69% of its workers, and it is considering strategic alternatives and restructuring for the purpose of cash conservation.
European regulators granted CE mark approval to ExThera Medical's Seraph 100 Microbind Affinity blood filter, which was shown in clinical studies to reduce pathogens during infections of the bloodstream. The decision allows the use of Seraph 100 as an adjunct to anti-infective treatment.
About 737 children have contracted the Ebola virus in the Democratic Republic of Congo's current outbreak, and more than 500 of them have died, according to the group Save the Children. Children account for 1 in 3 cases, and childhood mortality has accelerated in the past six months.
Researchers have developed a method for cultivating DNA damage-free cardiomyocytes outside the body for potential use in repairs of damage from heart attacks. Engraftments of the cells were successful in 14% of mice, compared with a rate of 7% for cardiomyocytes cultivated without culling cells with DNA damage, according to a study in the journal Circulation.
Results of a clinical trial in Africa demonstrated that transfusions of larger quantities of blood were associated with increased survival among children with nonfebrile severe, complicated anemia. The study in The New England Journal of Medicine compared transfusions of 30 milliliters per kilogram and 20 ml/kg, and researchers said the findings supported World Health Organization's 20 ml/kg recommendation for children with severe, complicated anemia with fever.
A study in the journal Neurology found that both low and high levels of hemoglobin were associated with greater long-term risk for dementia and Alzheimer's disease. The Netherlands study included 12,305 people who were followed for 12 years.
The International Coalition of Medicines Regulatory Authorities is urging health care professionals, researchers, global health leaders, industry and the media to take a One Health approach to the growing threat of antimicrobial resistance. In the US, the CMS finalized new Medicare coverage rules for 2020 intended to encourage innovation in the development of new antimicrobials.